Myeloid cells play a critical role in maintaining tissue homeostasis, regulating immunity and driving disease progression. The myeloid lineage was traditionally viewed as a group of sentinels of the innate immune system, consisting of multiple cell types, such as granulocytes, mononuclear phagocytes (monocytes, macrophages and dendritic cells), mast cells and megakaryocytes^[1]. Each cell type has specialized, often context-dependent functions. Recent research has redefined these cells as dynamic, multifunctional participants with tissue-specialized functions, which can mediate communication between immune and stromal compartments^[2].

Beyond their role in host defense, myeloid cells also help maintain tissue integrity, shape the tumor microenvironment, coordinate tissue repair and drive acute and chronic inflammation. Being adaptable and responsive to environmental signals, the cells become appealing targets for treating various diseases, including cancer, autoimmune disorders, infections and fibrosis.

As high-dimensional biology continues to redefine the frontiers of immunology, myeloid cell research stands at a pivotal juncture^[3,4]. Therefore, we present to you Myeloid Cells, a dedicated, gold open-access platform, hoping to accelerate discoveries, foster interdisciplinary collaboration and facilitate the translation of fundamental insights into clinical applications.

1. Why a Dedicated Journal for Myeloid Cells?

Over the past decade, myeloid biology has undergone a profound transformation. Single-cell and spatial transcriptomics, advanced imaging modalities, and lineage-tracing technologies have manifested the extraordinary diversity of myeloid subpopulations, developmental origins and trajectories and context-dependent functions. Simultaneously, in the field of translational immunology, myeloid cells have been employed as innovative therapeutic solutions, ranging from macrophage-targeted checkpoint inhibitors and nanoparticle-delivered RNA therapeutics to CAR-engineered myeloid cells which have entered early clinical trials.

Despite this momentum, myeloid cell research remains fragmented across journals focusing on narrower topics. Myeloid Cells seeks to bridge this gap by offering a central forum where discoveries about ontogeny, signaling, metabolism and therapeutic modulation are discussed. Our mission is to catalyze an interdisciplinary community, which means uniting immunologists, computational biologists, bioengineers and clinicians to accelerate discoveries and translation within the rapidly evolving field.

2. The Scope: From Embryonic Origins to Precision Therapies

Myeloid cells encompasses the full continuum of myeloid biology from developmental origins to therapeutic applications. We welcome studies that shed light on facets of myeloid cell research, including but not limited to:

• Fundamental Biology: Ontogeny, lineage fate mapping and single-cell state transitions.

• Tissue Contexts: Organ-specific adaptation, myeloid cells’ potential roles in cancer, fibrosis, infection and neurological disease.

• Mechanisms of Action: Signaling networks, metabolic pathways and cellular cross-talk with lymphoid and stromal cells.

• Technological Innovations: Advances that expand experimental and analytical frontiers in spatial and multi-omic profiling, imaging modalities, computational modeling and bioengineering.

• Therapeutic Frontiers: Strategies for myeloid cell reprogramming, CAR-macrophage design, induction of trained immunity and biomarker development.

Our tagline“Exploring the diversity, functions, and therapeutic potential of myeloid cells”reflects the journal’s ambition: to advance both the science and its translation into clinical applications.

3. Driving Translation and Impact

The primary mission of Myeloid Cells is to bridge the gap between basic and translational research. We encourage submissions that link cellular and molecular insights to clinical outcomes, utilize patient-derived samples to validate experimental results, or introduce novel preclinical models for therapeutic testing. Reviews, perspectives, and commentaries synthesizing state-of-the-art evidence across these translational interfaces will serve as authoritative guides for this fast-moving frontier.

By offering speedy yet rigorous peer review and full open access, Myeloid Cells is committed to ensuring that high-impact findings are immediately visible and citable, thereby accelerating the translation of scientific discoveries into real-world applications.

4. Fostering a Global Community

We envision Myeloid Cells not merely as a journal, but a hub for the expanding global community of scientists and clinicians dedicated to decoding and harnessing the myeloid compartment. Through thematic issues, webinars, and cross-disciplinary collaborations, we aim to nurture early-career researchers, spotlight rising leaders, and provide a forum for all ambitious, field-shaping ideas.

5. Looking Ahead

As we launch Myeloid Cells, several key themes emerge across our pages:

• A shift from static definitions to dynamic states shaped by microenvironments.

• Recognition of embryonic origins and monocyte-derived lineages as complementary systems.

• Integration of omics, spatial analysis and functional validation to uncover underlying mechanisms.

• Direct translation of myeloid biology into therapeutics—moving from concept to clinic.

These themes extend beyond academic interest, paving the way for novel diagnostic tools, next-generation immunotherapies and ultimately improved patient outcomes.

6. An Invitation to the Field

We cordially invite you, scientists, clinicians, and innovators, to make Myeloid Cells your home for transformative research. Submit your original articles, short communications, reviews, perspectives, and editorials. Propose Special Issues that gather the brightest minds in your domain. Join our Editorial Board or reviewer pool to help shape the discourse in this fast-evolving field.

Our collective efforts have the potential to redefine how we understand and leverage myeloid cells spanning the immune system, multiple organs, and a spectrum of diseases. Together, we can translate fundamental discoveries into impactful clinical advances.

7. Conclusion

The field of myeloid cell research is vibrant, diverse and primed for transformative impact. By launching Myeloid Cells, we aspire to offer a dedicated platform to advance this progress. We believe this journal will accelerate the translation from basic discoveries to therapeutic innovations, deepen our collective understanding of myeloid biology and help deliver novel treatment options to patients worldwide.

We look forward to your contributions and to collaborating with you to establish the premier destination for cutting-edge myeloid cell science.

Authors contribution

The authors contributed equally to this work.

Conflicts of interest

Florent Ginhoux and Lai Guan Ng serve as Editors-in-Chief of Myeloid Cells. The authors declare no other conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent for publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

None.

Copyright

©The Author(s) 2025.