Research progress on skin photoaging mechanisms and natural extracts

Jieyong Lai; Xingxuan Ren; Gaobin Liang; Shuhui Jia; Jiapeng Li; Yuwei Wang1,2，Huang Zhang; Weidong Xie

doi:10.70401/acrt.2026.0027

Research progress on skin photoaging mechanisms and natural extracts

Jieyong Lai

1,2,3,#

Xingxuan Ren

1,2,3,#

Gaobin Liang

Shuhui Jia

1,2,3

Jiapeng Li

1,2

Yuwei Wang1,2，Huang Zhang

1,2

Weidong Xie

1,2,3,*

Affiliation +

*Correspondence to: Weidong Xie, State Key Laboratory of Chemical Oncogenomics, Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, Guangdong, China. E-mail: xiewd@sz.tsinghua.edu.cn

Ageing Cancer Res Treat. 2026;3:202605. 10.70401/acrt.2026.0027

Received: January 23, 2026Accepted: June 16, 2026Published: June 17, 2026

This manuscript is made available in its unedited form to allow early access to the reported findings. Further editing will be completed before final publication. As such, the content may include errors, and standard legal disclaimers are applicable.

Abstract

Skin photoaging is a progressive, ultraviolet (UV)-driven form of extrinsic skin aging that compromises epidermal barrier integrity, dermal extracellular matrix organization, pigmentary homeostasis, and subcutaneous tissue support. Current findings indicate that photoaging is driven by interconnected molecular mechanisms, including ultraviolet A-(UVA)- and ultraviolet B (UVB)-induced reactive oxygen species (ROS) generation, DNA photolesions, mitogen-activated protein kinase/activator protein-1 (MAPK/AP-1-) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)-mediated inflammatory signaling, matrix metalloproteinase activation, collagen and elastin degradation, mitochondrial dysfunction, autophagy impairment, and senescence-associated secretory phenotypes (SASP). Plant-derived polyphenols, carotenoids, and terpenoids primarily attenuate oxidative stress and inflammatory signaling; marine-derived mycosporine-like amino acids, sulfated polysaccharides, xanthophylls, and collagen peptides provide UV absorption, matrix protection, and structural support; and microbiome-derived metabolites and probiotics modulate redox balance, immune signaling, and barrier homeostasis via the gut-skin axis. By integrating layer-specific pathogenesis with multi-source natural interventions, this review highlights translationally relevant strategies for developing safer, mechanism-guided anti-photoaging therapies, informing both preclinical research and clinical applications.

Keywords

Skin photoaging, ultraviolet radiation, oxidative stress, inflammation, natural products

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Lai J, Ren X, Liang G, Jia S, Li J, Zhang YW, et al. Research progress on skin photoaging mechanisms and natural extracts. Ageing Cancer Res Treat. 2026;3:202605. https://doi.org/10.70401/acrt.2026.0027

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Ageing and Cancer Research & Treatment

Research progress on skin photoaging mechanisms and natural extracts

Jieyong Lai

Xingxuan Ren

Gaobin Liang

Shuhui Jia

Jiapeng Li

Yuwei Wang1,2，Huang Zhang

Weidong Xie

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Ageing and Cancer Research & Treatment

Research progress on skin photoaging mechanisms and natural extracts

Jieyong Lai

Xingxuan Ren

Gaobin Liang

Shuhui Jia

Jiapeng Li

Yuwei Wang1,2，Huang Zhang

Weidong Xie

Abstract

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