Advances in the catalytic asymmetric synthesis of chiral sulfur compounds bearing S=N bonds
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Advances in the catalytic asymmetric synthesis of chiral sulfur compounds bearing S=N bonds

Guofeng Zhao
1
,
Yutong Zhao
1
,
Xiaorui Ren
1
,
Qianyu Zhang
1
,
Chang Lu
1
,
Bing Xu
2,*
,
Zhanming Zhang
3,4,*
*Correspondence to: Bing Xu, School of Pharmacy, Naval Medical University, Shanghai 200433, China. E-mail: xubing_0520@163.com
Zhanming Zhang, Department of Chemistry, Fudan University, Shanghai 200438, China; Fudan Zhangjiang Institute, Shanghai 201203, China. E-mail: zhanmingzhang@fudan.edu.cn
Chiral Chem. 2027;3:202642. 10.70401/cc.2026.0044
Received: September 08, 2026Accepted: October 21, 2026Published: October 22, 2026
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This manuscript is made available in its unedited form to allow early access to the reported findings. Further editing will be completed before final publication. As such, the content may include errors, and standard legal disclaimers are applicable.

Abstract

Chiral sulfur(IV) and sulfur(VI) compounds bearing S=N bonds are important structural units in drug discovery, materials science, and asymmetric catalysis. The presence of a stereogenic sulfur atom increases the three-dimensional complexity of molecules, allowing for the precise tuning of their physicochemical properties and biological target-binding affinities. However, the highly stereoselective construction of these high-valent sulfur centers has long been a significant synthetic challenge. This review summarizes recent progress, primarily covering literature from 2020 to 2026, in the catalytic asymmetric synthesis of chiral sulfur compounds bearing S=N bonds. For S(IV) motifs including sulfilimines, sulfinamidines, and sulfinimidate esters, we examine advances in transition-metal catalysis and organocatalysis, highlighting recent breakthroughs in radical cross-coupling and direct asymmetric amination. For S(VI) frameworks including sulfoximines, sulfonimidamides, sulfonimidate esters, and sulfonimidoyl fluorides, the discussion covers asymmetric C–H functionalization, dynamic kinetic asymmetric transformations (DyKAT), and stereospecific oxidative transfers from enantioenriched S(IV) precursors. We highlight stereocontrol strategies, reaction mechanisms, and substrate scopes. We also discuss current limitations and suggest possible directions for future work, with an emphasis on more sustainable catalytic methods and modular strategies for building new functional molecules.

Keywords

Asymmetric catalysis, sulfur stereocenters, sulfilimines, sulfoximines, sulfonimidamides

References

  • 1. Scott KA, Njardarson JT. Analysis of US FDA-approved drugs containing sulfur atoms. Top Curr Chem. 2018;376(1):5.
    [DOI] [PubMed]
  • 2. Boyd DA. Sulfur and its role in modern materials science. Angew Chem Int Ed Engl. 2016;55(50):15486-15502.
    [DOI] [PubMed]
  • 3. Devendar P, Yang GF. Sulfur-containing agrochemicals. Top Curr Chem. 2017;375(6):82.
    [DOI] [PubMed]
  • 4. Han J, Soloshonok VA, Klika KD, Drabowicz J, Wzorek A. Chiral sulfoxides: Advances in asymmetric synthesis and problems with the accurate determination of the stereochemical outcome. Chem Soc Rev. 2018;47(4):1307-1350.
    [DOI] [PubMed]
  • 5. Zhang X, Wang F, Tan CH. Asymmetric synthesis of S(IV) and S(VI) stereogenic centers. JACS Au. 2023;3(3):700-714.
    [DOI] [PubMed] [PMC]
  • 6. Mäder P, Kattner L. Sulfoximines as rising stars in modern drug discovery? Current status and perspective on an emerging functional group in medicinal chemistry. J Med Chem. 2020;63(23):14243-14275.
    [DOI] [PubMed]
  • 7. Han Y, Xing K, Zhang J, Tong T, Shi Y, Cao H, et al. Application of sulfoximines in medicinal chemistry from 2013 to 2020. Eur J Med Chem. 2021;209:112885.
    [DOI] [PubMed]
  • 8. Greenwood NS, Boyer ZW, Ellman JA, Gnamm C. Sulfilimines from a medicinal chemist’s perspective: Physicochemical and in vitro parameters relevant for drug discovery. J Med Chem. 2025;68(4):4079-4100.
    [DOI] [PubMed] [PMC]
  • 9. Chen J, Li Y, Li J, Tao J, Zhou X, Wang W, et al. Recent advances in the synthesis and N-functionalization of sulfonimidamides. Asian J Org Chem. 2025;14(11):e00535.
    [DOI]
  • 10. Borekci A, Kuru Bektasoglu P, Somay A, Hazneci J, Gürer B. Esomeprazole’s antifibrotic effects on rats with epidural fibrosis. Global Spine J. 2025;15(5):2611-2616.
    [DOI] [PubMed] [PMC]
  • 11. de Alwis N, Fato BR, Beard S, Binder NK, Kaitu’u-Lino TJ, Onda K, et al. Assessment of the proton pump inhibitor, esomeprazole magnesium hydrate and trihydrate, on pathophysiological markers of preeclampsia in preclinical human models of disease. Int J Mol Sci. 2022;23(17):9533.
    [DOI] [PubMed] [PMC]
  • 12. Fang Y, He X, Peng A, Yang YQ, Xiang J. Association study of esomeprazole pharmacokinetics and CYP2C19 gene polymorphisms. Clin Pharmacol Drug Dev. 2024;13(2):134-139.
    [DOI] [PubMed]
  • 13. Lücking U. Sulfoximines: A neglected opportunity in medicinal chemistry. Angew Chem Int Ed Engl. 2013;52(36):9399-9408.
    [DOI] [PubMed]
  • 14. Ao W, Kim HI, Tommarello D, Conrads KA, Hood BL, Litzi T, et al. Metronomic dosing of ovarian cancer cells with the ATR inhibitor AZD6738 leads to loss of CDC25A expression and resistance to ATRi treatment. Gynecol Oncol. 2023;177:60-71.
    [DOI] [PubMed]
  • 15. Wang Q, Peng Y, Wang S, Xu J, Cheng C, Luo X, et al. Exploring the efficacy of AZD6738 in corneal neovascularization: Autophagy enhancement and angiogenesis inhibition. J Ocul Pharmacol Ther. 2025;41(8):444-454.
    [DOI] [PubMed]
  • 16. Luecking UT, Scholz A, Kosemund D, Bohlmann R, Briem H, Lienau P, et al. Abstract 984: Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: From p.o. to i.v. Cancer Res. 2017;77(13_Supplement):984.
    [DOI]
  • 17. Diamond JR, Moreno V, Lim EA, Cordoba R, Cai C, Ince SJ, et al. Phase I dose escalation study of the first-in-class selective PTEFb inhibitor BAY 1251152 in patients with advanced cancer: Novel target validation and early evidence of clinical activity. J Clin Oncol. 2018;36(15_suppl):2507.
    [DOI]
  • 18. Bartoszyk GD, Dooley DJ, Barth H, Hartenstein J, Satzinger G. Stereoselective pharmacological effects and benzodiazepine receptor affinity of the enantiomers of Gö 4962. J Pharm Pharmacol. 1987;39(5):407-408.
    [DOI] [PubMed]
  • 19. Bartoszyk GD, Schoenherr U. Differential effects of competitive benzodiazepine receptor antagonists on the anticonflict activity of Gö 4962. Behav Neural Biol. 1987;48(2):317-319.
    [DOI] [PubMed]
  • 20. Madurka I, Vishnevsky A, Soriano JB, Gans SJ, Ore DJS, Rendon A, et al. DFV890: A new oral NLRP3 inhibitor: Tested in an early phase 2a randomised clinical trial in patients with COVID-19 pneumonia and impaired respiratory function. Infection. 2023;51(3):641-654.
    [DOI] [PubMed] [PMC]
  • 21. Gatlik E, Mehes B, Voltz E, Sommer U, Tritto E, Lestini G, et al. First-in-human safety, tolerability, and pharmacokinetic results of DFV890, an oral low-molecular-weight NLRP3 inhibitor. Clin Transl Sci. 2024;17(5):e13789.
    [DOI] [PubMed] [PMC]
  • 22. Shen DM, Byth KF, Bertheloot D, Braams S, Bradley S, Dean D, et al. Discovery of DFV890, a potent sulfonimidamide-containing NLRP3 inflammasome inhibitor. J Med Chem. 2025;68(5):5529-5550.
    [DOI] [PubMed]
  • 23. Xu LW, Li L, Lai GQ, Jiang JX. The recent synthesis and application of silicon-stereogenic silanes: A renewed and significant challenge in asymmetric synthesis. Chem Soc Rev. 2011;40(3):1777-1790.
    [DOI] [PubMed]
  • 24. Ye ZT, Wu ZW, Zhang XX, Zhou J, Yu JS. Organocatalytic enantioselective construction of Si-stereocenters: Recent advances and perspectives. Chem Soc Rev. 2024;53(17):8546-8562.
    [DOI] [PubMed]
  • 25. Zu B, Guo Y, Ren LQ, Li Y, He C. Catalytic enantioselective synthesis of boron-stereogenic BODIPYs. Nat Synth. 2023;2(6):564-571.
    [DOI]
  • 26. Dutartre M, Bayardon J, Jugé S. Applications and stereoselective syntheses of P-chirogenic phosphorus compounds. Chem Soc Rev. 2016;45(20):5771-5794.
    [DOI] [PubMed]
  • 27. Furukawa N, Oae S. Sulfilimines. Synthetic applications and potential utilizations. Ind Eng Chem Prod Res Dev. 1981;20(2):260-270.
    [DOI]
  • 28. Shi Y, Zheng S, Huang J, He FS, Yang M, Wu J. Catalytic asymmetric synthesis of chiral sulfilimines via S-C bond formation. Org Chem Front. 2025;12(3):953-959.
    [DOI]
  • 29. Yu X, Zhang Y, Liu Y, Li Y, Wang Q. Synthesis and acaricidal- and insecticidal-activity evaluation of novel oxazolines containing sulfiliminyl moieties and their derivatives. J Agric Food Chem. 2019;67(15):4224-4231.
    [DOI] [PubMed]
  • 30. Wang B, Liang X, Zeng Q. Recent advances in the synthesis of cyclic sulfoximines via C-H bond activation. Molecules. 2023;28(3):1367.
    [DOI] [PubMed] [PMC]
  • 31. Wang CR, Sun JN, Li Y, Li JH. Recent advances in catalytic asymmetric synthesis of chiral sulfinyl compounds. Eur J Org Chem. 2025;28(27):e202500378.
    [DOI]
  • 32. Zheng W, Chen X, Chen F, He Z, Zeng Q. Syntheses and transformations of sulfoximines. Chem Rec. 2021;21(2):396-416.
    [DOI] [PubMed]
  • 33. Zhu RH, Shi XX. Practical and highly stereoselective method for the preparation of several chiral arylsulfinamides and arylsulfinates based on the spontaneous crystallization of diastereomerically pure N-benzyl-N-(1-phenylethyl)-arylsulfinamides. Tetrahedron Asymmetry. 2011;22(4):387-393.
    [DOI]
  • 34. Takada H, Oda M, Oyamada A, Ohe K, Uemura S. Catalytic diastereoselective sulfimidation of diaryl sulfides and application of chiral sulfimides to asymmetric allylic alkylation. Chirality. 2000;12(5-6):299-312.
    [DOI] [PubMed]
  • 35. McGrath MJ, Bolm C. The use of chiral lithium amides in the desymmetrisation of N-trialkylsilyl dimethyl sulfoximines. Beilstein J Org Chem. 2007;3:33.
    [DOI] [PubMed] [PMC]
  • 36. Das A, Dhakal SK, Trevino R, Fremin SO, Nguyen VTB, Porey A, et al. Enantioconvergent access to chiral S(VI) stereocenters by kinetic resolution of sulfonimidoyl chlorides. Angew Chem Int Ed Engl. 2026;65(2):e19733.
    [DOI] [PubMed] [PMC]
  • 37. Ellman JA, Owens TD, Tang TP. N-tert-butanesulfinyl imines:   Versatile intermediates for the asymmetric synthesis of amines. Acc Chem Res. 2002;35(11):984-995.
    [DOI] [PubMed]
  • 38. Suleman M, Huang T, Zhou T, Chen Z, Shi B. Recent advances in asymmetric synthesis of chiral-at-sulfur sulfoximines. ACS Catal. 2025;15(7):5511-5530.
    [DOI]
  • 39. Symes OL, Bull JA. The stereochemistry of substitution at S(VI). Org Chem Front. 2025;12(23):6681-6697.
    [DOI]
  • 40. Dong J, Krasnova L, Finn MG, Sharpless KB. Sulfur(VI) fluoride exchange (SuFEx): Another good reaction for click chemistry. Angew Chem Int Ed Engl. 2014;53(36):9430-9448.
    [DOI] [PubMed]
  • 41. Wang J, Frings M, Bolm C. Enantioselective nitrene transfer to sulfides catalyzed by a chiral iron complex. Angew Chem Int Ed Engl. 2013;52(33):8661-8665.
    [DOI] [PubMed]
  • 42. Yoshitake M, Hayashi H, Uchida T. Ruthenium-catalyzed asymmetric N-acyl nitrene transfer reaction: Imidation of sulfide. Org Lett. 2020;22(10):4021-4025.
    [DOI] [PubMed]
  • 43. Annapureddy RR, Burg F, Gramüller J, Golub TP, Merten C, Huber SM, et al. Silver-catalyzed enantioselective sulfimidation mediated by hydrogen bonding interactions. Angew Chem Int Ed Engl. 2021;60(14):7920-7926.
    [DOI] [PubMed] [PMC]
  • 44. Liu Z, Wu H, Zhang H, Wang F, Liu X, Dong S, et al. Iron-catalyzed asymmetric imidation of sulfides via sterically biased nitrene transfer. J Am Chem Soc. 2024;146(26):18050-18060.
    [DOI] [PubMed]
  • 45. Yuan Y, Han Y, Zhang ZK, Sun S, Wu K, Yang J, et al. Enantioselective arylation of sulfenamides to access sulfilimines enabled by palladium catalysis. Angew Chem Int Ed Engl. 2024;63(37):e202409541.
    [DOI] [PubMed]
  • 46. Liang Q, Zhang X, Rotella ME, Xu Z, Kozlowski MC, Jia T. Enantioselective Chan–lam S-arylation of sulfenamides. Nat Catal. 2024;7(9):1010-1020.
    [DOI] [PubMed] [PMC]
  • 47. Han M, Zhang SQ, Cui X, Tang Z, Li GX. Synthesis of chiral sulfilimines via copper-catalyzed enantiospecific arylation of sulfenamides. J Org Chem. 2025;90(38):13440-13448.
    [DOI] [PubMed]
  • 48. Wu XB, Shen Y, Jiang HJ, Gong LZ. Cu-catalyzed enantioselective S-arylation of sulfenamides enabled by confined ligands. Org Lett. 2025;27(12):2845-2851.
    [DOI] [PubMed]
  • 49. Liu X, Ye Z, Liu J, Wu Y, Zhang F. Asymmetric synthesis of biaryl sulfilimines bearing multiple chiral elements involving cyclic diaryliodoniums. Org Lett. 2025;27(25):6695-6701.
    [DOI] [PubMed]
  • 50. Fang W, Meng YD, Ding SY, Wang JY, Pei ZH, Shen ML, et al. Asymmetric S-arylation of sulfenamides to access axially chiral sulfilimines enabled by anionic stereogenic-at-cobalt(III) complexes. Angew Chem Int Ed Engl. 2025;64(7):e202419596.
    [DOI] [PubMed]
  • 51. Wang Y, Mu Y, Han X, Xiao J, Huang G, Wang F, et al. Copper-catalyzed asymmetric C-H sulfilimination of arenes via HAT-primed C-S radical-radical coupling. J Am Chem Soc. 2025;147(42):38931-38941.
    [DOI] [PubMed]
  • 52. Wang W, Yang Q, Yao Y, Hu L, Jiang M, Tan J, et al. Access to axially chiral vinyl sulfilimines via copper-catalyzed enantioselective radical relay trifluoromethyl-sulfilimination of terminal alkynes. Angew Chem Int Ed Engl. 2026;65(8):e23530.
    [DOI] [PubMed]
  • 53. Fan LW, Tang JB, Wang LL, Gao Z, Liu JR, Zhang YS, et al. Copper-catalysed asymmetric cross-coupling reactions tolerant of highly reactive radicals. Nat Chem. 2026;18(1):142-151.
    [DOI] [PubMed]
  • 54. Wang F, Xiang W, Xie Y, Huai L, Zhang L, Zhang X. Synthesis of chiral sulfilimines by organocatalytic enantioselective sulfur alkylation of sulfenamides. Sci Adv. 2024;10(37):eadq2768.
    [DOI] [PubMed] [PMC]
  • 55. Champlin AT, Kwon NY, Ellman JA. Enantioselective S-alkylation of sulfenamides by phase-transfer catalysis. Angew Chem Int Ed Engl. 2024;63(42):e202408820.
    [DOI] [PubMed] [PMC]
  • 56. Patel S, Greenwood NS, Mercado BQ, Ellman JA. Rh(II)-catalyzed enantioselective S-alkylation of sulfenamides with acceptor-acceptor diazo compounds enables the synthesis of sulfoximines displaying diverse functionality. Org Lett. 2024;26(29):6295-6300.
    [DOI] [PubMed] [PMC]
  • 57. Cui WL, Zhang L, Liu C, Su J, Zhang HR, Ma R, et al. Reagent-regulated organocatalytic enantiodivergent synthesis of chiral sulfinimidate esters. J Am Chem Soc. 2025;147(23):19986-19995.
    [DOI] [PubMed]
  • 58. Xiong Q, Liao M, Zhao S, Wu S, Hong Y, Chi YR, et al. Asymmetric synthesis of S(IV)-stereogenic sulfinimidate esters by sulfinamide activation. Angew Chem Int Ed Engl. 2025;64(21):e202500170.
    [DOI] [PubMed]
  • 59. Jiang HJ, Tu XQ, Kong XY, Wang JY, Liu YY, Shen ML, et al. Catalytic synthesis of chiral sulfinimidate esters via oxidative esterification of sulfenamides. Nat Commun. 2025;16(1):6988.
    [DOI] [PubMed] [PMC]
  • 60. Fan FX, Jia SM, Mo Z, Wang F. Iron-catalyzed asymmetric NH2-amination of sulfenamides. Angew Chem Int Ed Engl. 2026;65(33):e1625296.
    [DOI] [PubMed] [PMC]
  • 61. Sun Y, Cramer N. Enantioselective synthesis of chiral-at-sulfur 1, 2-benzothiazines by CpxRhIII-catalyzed C–H functionalization of sulfoximines. Angew Chem Int Ed Engl. 2018;57(47):15539-15543.
    [DOI] [PubMed]
  • 62. Shen B, Wan B, Li X. Enantiodivergent desymmetrization in the rhodium(III)-catalyzed annulation of sulfoximines with diazo compounds. Angew Chem Int Ed Engl. 2018;57(47):15534-15538.
    [DOI] [PubMed]
  • 63. Brauns M, Cramer N. Efficient kinetic resolution of sulfur-stereogenic sulfoximines by exploiting cpXRhIII-catalyzed C–H functionalization. Angew Chem Int Ed Engl. 2019;58(26):8902-8906.
    [DOI] [PubMed]
  • 64. Zhou T, Qian PF, Li JY, Zhou YB, Li HC, Chen HY, et al. Efficient synthesis of sulfur-stereogenic sulfoximines via Ru(II)-catalyzed enantioselective C-H functionalization enabled by chiral carboxylic acid. J Am Chem Soc. 2021;143(18):6810-6816.
    [DOI] [PubMed]
  • 65. Li JY, Xie PP, Zhou T, Qian PF, Zhou YB, Li HC, et al. Ir(III)-catalyzed asymmetric C–H activation/annulation of sulfoximines assisted by the hydrogen-bonding interaction. ACS Catal. 2022;12(15):9083-9091.
    [DOI]
  • 66. Qian PF, Zhou T, Li JY, Zhou YB, Shi BF. Ru(II)/chiral carboxylic acid-catalyzed asymmetric [4 + 3] annulation of sulfoximines with α, β-unsaturated ketones. ACS Catal. 2022;12(22):13876-13883.
    [DOI]
  • 67. Hirata Y, Sekine D, Kato Y, Lin L, Kojima M, Yoshino T, et al. Cobalt(III)/chiral carboxylic acid-catalyzed enantioselective synthesis of benzothiadiazine-1-oxides via C–H activation. Angew Chem Int Ed Engl. 2022;61(28):e202205341.
    [DOI] [PubMed]
  • 68. Murata A, Endo T, Hirata Y, Higashida K, Yoshino T, Matsunaga S. Enantioselective C–H amidation of sulfondiimines for the synthesis of 1, 2, 4-benzothiadiazine-1-imines under cobalt catalysis. Org Chem Front. 2025;12(15):4236-4241.
    [DOI]
  • 69. Gutierrez DA, Toth-Williams G, Laconsay CJ, Yasuda M, Fettinger JC, Di Maso MJ, et al. Desymmetrization of cyclic sulfonimidamides by asymmetric allylation. Angew Chem Int Ed Engl. 2024;63(34):e202407114.
    [DOI] [PubMed]
  • 70. Zeng D, Zhang X, Wang M, Jiang X. Asymmetric S=N-embedded polyaromatic construction via enantioselective Pd-catalyzed C-H activation. Nat Commun. 2025;16(1):3046.
    [DOI] [PubMed] [PMC]
  • 71. Xia Y, Xu B, Zhang Z, Zhang J. Pd/Ag dual-catalyzed asymmetric synthesis of sulfur-stereogenic sulfoximines via enantioselective intramolecular C-H arylation. Green Synth Catal. 2025.
    [DOI]
  • 72. Fang S, Liu Z, Zhang H, Pan J, Chen Y, Ren X, et al. Access to S-stereogenic free sulfoximines via bifunctional phosphonium salt-catalyzed desymmetrization of bisphenols. ACS Catal. 2021;11(22):13902-13912.
    [DOI]
  • 73. Tang Y, Miller SJ. Catalytic enantioselective synthesis of pyridyl sulfoximines. J Am Chem Soc. 2021;143(24):9230-9235.
    [DOI] [PubMed] [PMC]
  • 74. Tilby MJ, Dewez DF, Hall A, Martínez Lamenca C, Willis MC. Exploiting configurational lability in aza-sulfur compounds for the organocatalytic enantioselective synthesis of sulfonimidamides. Angew Chem Int Ed Engl. 2021;60(49):25680-25687.
    [DOI] [PubMed] [PMC]
  • 75. van Dijk L, Haas BC, Lim NK, Clagg K, Dotson JJ, Treacy SM, et al. Data science-enabled palladium-catalyzed enantioselective aryl-carbonylation of sulfonimidamides. J Am Chem Soc. 2023;145(38):20959-20967.
    [DOI] [PubMed]
  • 76. Haas BC, Lim NK, Jermaks J, Gaster E, Guo MC, Malig TC, et al. Enantioselective sulfonimidamide acylation via a cinchona alkaloid-catalyzed desymmetrization: Scope, data science, and mechanistic investigation. J Am Chem Soc. 2024;146(12):8536-8546.
    [DOI] [PubMed] [PMC]
  • 77. Guo CM, Zhang FY, Tian Y, Xie MS, Guo HM. Pyridine-N-oxide catalyzed asymmetric N-acylative desymmetrization of sulfonimidamides. Chem Sci. 2025;16(20):8812-8819.
    [DOI] [PubMed] [PMC]
  • 78. Yang GF, Yuan Y, Tian Y, Zhang SQ, Cui X, Xia B, et al. Synthesis of chiral sulfonimidoyl chloride via desymmetrizing enantioselective hydrolysis. J Am Chem Soc. 2023;145(9):5439-5446.
    [DOI] [PubMed]
  • 79. Peng Z, Sun S, Zheng MM, Li Y, Li X, Li S, et al. Enantioselective sulfur(VI) fluoride exchange reaction of iminosulfur oxydifluorides. Nat Chem. 2024;16(3):353-362.
    [DOI] [PubMed]
  • 80. Huang HS, Yuan Y, Wang W, Zhang SQ, Nie XK, Yang WT, et al. Enantioselective synthesis of chiral sulfonimidoyl fluorides facilitates stereospecific SuFEx click chemistry. Angew Chem Int Ed Engl. 2025;64(4):e202415873.
    [DOI] [PubMed]
  • 81. Lian SY, Li N, Tian Y, Xie MS, Guo HM. Zn(II)-catalyzed enantioselective nucleophilic substitution reactions: Access to sulfur(VI)-stereogenic sulfonimidate esters. Angew Chem Int Ed Engl. 2026;65(3):e21905.
    [DOI] [PubMed]
  • 82. Li N, Lian SY, Wei T, Li WJ, Zhang JH, Wang DC, et al. Catalytic asymmetric sulfonimidoyl transfer to access chiral sulfonimidoyl fluorides and related derivatives. Nat Chem. 2026;18(5):882-892.
    [DOI] [PubMed]

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Zhao G, Zhao Y, Ren X, Zhang Q, Lu C, Xu B, et al. Advances in the catalytic asymmetric synthesis of chiral sulfur compounds bearing S=N bonds. Chiral Chem. 2027;3:202642. https://doi.org/10.70401/cc.2026.0044

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