Special Issue Information

This Special Issue is inspired by the “Quantitative Approaches and Understudied Questions in the Biology of Aging” workshop, an event designed to champion underappreciated, fundamental questions in the biology of aging. Stepping back from translational and applied research largely emphasised today, the workshop convened leading physicists, computational biologists, and experimentalists in a collaborative, un-conference format to foster cross-disciplinary dialogue. Central themes included the biology of biostasis and diapause as related to aging, the possible mechanisms of germline immortality, the role of the extracellular matrix, sex-specific aging of the immune system, and the critical re-evaluation of aging clocks through a mechanistic lens. A core objective was to integrate first-principles modeling with experimental data to define a new roadmap for the field.

This Issue collects contributions emerging from these discussions, providing a platform for research that leverages quantitative, physics-driven approaches to illuminate the core mechanisms of aging.

Keyword of the Special Issue include but are not limited to:
• Fundamental Mechanisms of Aging; 
• Universal Aging Laws;
• Biostasis, Hibernation and Late Resilience in Aging;
• Meiotic Rejuvenation;
• Germline Immortality; 
• First-Principles Modeling;
• Extracellular Matrix; 
• Immune Aging;
• Intervention Testing;
• Germline / Soma Tradeoffs;
• Regeneration and Aging;
• Remicrovascularization;
• Cross-Disciplinary Research

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